Markku Laakso Selected Research

Glucose Intolerance

1/2021	SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice.
1/2021	Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
1/2021	Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study.
1/2021	Effect of lifestyle intervention on the risk of incident diabetes in individuals with impaired fasting glucose and low or high genetic risk for the development of type 2 diabetes in men: a T2D-GENE trial.
10/2015	Influence of endogenous NEFA on beta cell function in humans.
11/2013	A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.
9/2013	Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.
2/2012	Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the Finnish Diabetes Prevention Study.
8/2010	Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study.
6/2010	Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects.

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Markku Laakso Research Topics

Disease

133	Type 2 Diabetes Mellitus (MODY) 01/2022 - 02/2002
111	Insulin Resistance 01/2022 - 01/2002
50	Obesity 01/2022 - 05/2003
42	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 09/2004
32	Glucose Intolerance 01/2021 - 06/2002
24	Cardiovascular Diseases (Cardiovascular Disease) 12/2021 - 02/2002
21	Hyperglycemia 01/2022 - 07/2003
17	Coronary Disease (Coronary Heart Disease) 01/2019 - 02/2002
15	Inflammation (Inflammations) 10/2022 - 10/2007
14	Hyperinsulinism (Hyperinsulinemia) 01/2021 - 07/2003
13	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019 - 01/2002
10	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2015 - 07/2002
9	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2002
9	Heart Failure 01/2021 - 05/2004
8	Stroke (Strokes) 11/2021 - 10/2005
8	Atherosclerosis 01/2021 - 09/2004
8	Myocardial Infarction 03/2015 - 10/2005
7	Genetic Risk Score 02/2022 - 05/2011
7	Weight Loss (Weight Reduction) 11/2021 - 08/2005
6	Hypertension (High Blood Pressure) 01/2017 - 07/2003
6	Hypertrophy 01/2015 - 01/2003
6	Necrosis 08/2012 - 06/2005
6	Abdominal Obesity 05/2010 - 07/2005
5	Non-alcoholic Fatty Liver Disease 11/2021 - 03/2012
5	Dyslipidemias (Dyslipidemia) 01/2021 - 05/2003
4	Atherosclerotic Plaque (Atheroma) 01/2021 - 03/2002
4	Fatty Liver 01/2020 - 10/2011
4	Ischemia 01/2017 - 04/2010
4	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2014 - 08/2005
4	Pre-Eclampsia (Preeclampsia) 09/2006 - 10/2002
3	Albuminuria 01/2021 - 01/2010
3	Prediabetic State (Prediabetes) 01/2021 - 01/2019
3	Cognitive Dysfunction 10/2020 - 01/2018
3	Cardiomyopathies (Cardiomyopathy) 01/2020 - 01/2004
3	Alcoholic Fatty Liver 05/2016 - 03/2012

Drug/Important Bio-Agent (IBA)

100	Glucose (Dextrose)FDA LinkGeneric 02/2021 - 01/2002
60	Insulin (Novolin)FDA Link 01/2022 - 01/2002
39	LipidsIBA 12/2021 - 02/2002
26	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2004
21	Proteins (Proteins, Gene)FDA Link 11/2021 - 07/2002
21	CholesterolIBA 01/2017 - 02/2002
19	AdiponectinIBA 01/2020 - 12/2004
17	Fatty Acids (Saturated Fatty Acids)IBA 10/2022 - 07/2006
17	Triglycerides (Triacylglycerol)IBA 01/2018 - 02/2002
13	Messenger RNA (mRNA)IBA 01/2021 - 04/2010
12	C-Reactive ProteinIBA 01/2021 - 12/2004
12	HDL CholesterolIBA 01/2018 - 02/2002
12	Lipoproteins (Lipoprotein)IBA 12/2017 - 02/2002
12	PPAR gammaIBA 04/2009 - 10/2002
10	LDL CholesterolIBA 02/2022 - 02/2002
9	HexokinaseIBA 01/2017 - 07/2005
8	oxidized low density lipoproteinIBA 02/2022 - 04/2004
8	Nonesterified Fatty Acids (NEFA)IBA 01/2021 - 05/2003
8	EnzymesIBA 01/2020 - 01/2011
8	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2019 - 02/2002
8	CytokinesIBA 06/2013 - 07/2003
8	Interleukin-6 (Interleukin 6)IBA 04/2008 - 02/2003
7	Pharmaceutical PreparationsIBA 12/2021 - 02/2002
7	ProinsulinIBA 06/2015 - 09/2009
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2010 - 07/2003
6	Linoleic Acid (Linoleate)IBA 10/2022 - 11/2013
6	Biological ProductsIBA 12/2021 - 01/2017
6	TropomyosinIBA 09/2014 - 01/2003
6	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2007 - 07/2002
6	Acarbose FDA LinkGeneric 04/2007 - 06/2002
5	Tyrosine (L-Tyrosine)FDA Link 11/2021 - 07/2012
5	Amino Acids FDA Link 11/2021 - 07/2012
5	Alanine (L-Alanine)FDA Link 11/2021 - 10/2006
5	HDL LipoproteinsIBA 01/2018 - 02/2002
4	Glutamine (L-Glutamine)FDA Link 11/2021 - 07/2012
4	RNA (Ribonucleic Acid)IBA 01/2021 - 05/2011
4	P-2 (P 2)IBA 08/2020 - 02/2010
4	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2017 - 01/2007
4	Cholestanol (Coprostanol)IBA 08/2010 - 03/2004
3	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2021 - 05/2015
3	alpha-Linolenic Acid (Linolenic Acid)IBA 01/2021 - 01/2014
3	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021 - 11/2015
3	Simvastatin (Zocor)FDA LinkGeneric 11/2020 - 01/2015
3	Amyloid (Amyloid Fibrils)IBA 10/2020 - 07/2017
3	Hormones (Hormone)IBA 01/2020 - 01/2012
3	Glutamic Acid (Glutamate)FDA Link 01/2019 - 02/2015
3	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2019 - 06/2013
3	Isoleucine (L-Isoleucine)FDA Link 01/2019 - 07/2012
3	Antihypertensive Agents (Antihypertensives)IBA 01/2019 - 05/2010
3	ApolipoproteinsIBA 10/2018 - 06/2011
3	Leucine (L-Leucine)FDA Link 01/2018 - 03/2002
3	Sirtuin 1IBA 12/2017 - 12/2006
3	Cholesterol Esters (Cholesteryl Esters)IBA 12/2017 - 11/2015
3	DNA (Deoxyribonucleic Acid)IBA 10/2017 - 07/2003
3	Transcription Factors (Transcription Factor)IBA 01/2017 - 04/2004
3	trimethyloxamine (trimethylamine N-oxide)IBA 01/2017 - 01/2017
3	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2017 - 03/2012
3	Blood Glucose (Blood Sugar)IBA 04/2015 - 11/2010
3	Fenofibrate (CiL)FDA LinkGeneric 03/2015 - 05/2009
3	Carrier Proteins (Binding Protein)IBA 01/2015 - 07/2002
3	Cardiac MyosinsIBA 01/2015 - 07/2002
3	Ventricular MyosinsIBA 09/2014 - 12/2004

Therapy/Procedure

4	Glycemic Control 09/2017 - 02/2007
4	Therapeutics 02/2017 - 07/2004
4	Surgical Amputation (Amputations) 03/2015 - 10/2005